Welcome to PROTEUS2|
PROTEUS2 is a web server designed to support comprehensive protein structure prediction and structure-based annotation.
PROTEUS2 accepts either single sequences (for directed studies) or multiple sequences (for whole proteome annotation)
and predicts the secondary and, if possible, tertiary structure of the query protein(s). Unlike most other tools or
servers, PROTEUS2 bundles signal peptide identification, transmembrane helix prediction, transmembrane β-strand
prediction, secondary structure prediction (for soluble proteins) and homology modeling (i.e. 3D structure generation)
into a single prediction pipeline. Using a combination of progressive multi-sequence alignment, structure-based mapping,
hidden Markov models, multi-component neural nets and up-to-date databases of known secondary structure assignments,
PROTEUS2 is able to achieve among the highest reported levels of predictive accuracy for signal peptides (Q2=94%),
membrane spanning helices (Q2=87%) and secondary structure (Q3 score of 81.3% ). PROTEUS2's homology modeling
services also provide high quality 3D models that compare favorably with those generated by SWISS-MODEL
(within 0.2 Å RMSD).
The average PROTEUS2 prediction takes ~2 minutes per query sequence. Source code is also freely available here.
PROTEUS2 Queue Information = Currently 4820 sequences are in queue.